Is PCOS associated with metabolic syndrome?
Polycystic
ovarian syndrome affects 15% of reproductive-age women. Insulin resistance
appears to play a role in the development of PCOS and the metabolic syndrome
that follows. In women with PCOS, the prevalence of metabolic syndrome is as
high as 30%, and it is linked to long-term repercussions such as cardiovascular
disease, type 2 diabetes, malignancies, sleep apnea, and psychiatric issues. In
the past, PCOS treatment has primarily focused on infertility, anovulation, and
hirsutism; therefore, clinicians must be more cognizant of metabolic syndrome.
Because of the seriousness of metabolic syndrome's health consequences, early
detection and intervention are essential.
Pathophysiology
To
explore the evolution of metabolic
syndrome in PCOS, several pathways have been postulated. Understanding the
underlying pathophysiology of the various components of metabolic syndrome is
critical due to the complex systemic interconnections between them. Insulin
resistance, Atherogenic dyslipidaemia, Obesity
and Hypertension are the main reasons leading to consequences
like Cardiovascular diseases, Diabetes,
Cancers, Obstructive sleep apnoea and Psychological problems.
Management
The
addition of metabolic syndrome to the rising epidemics of diabetes type II and
cardiovascular disease (CVD) makes early and focused treatment a medical
necessity. Adopting lifestyle adjustments that may prevent or reduce the
progression of adverse outcomes in high-risk patients is the primary strategy
for metabolic syndrome. Medical
management of metabolic syndrome can be achieved with Insulin-sensitising
agents, Anti-obesity agents and Statins
The
hunt for innovative modalities to treating metabolic syndrome in women with
PCOS has been fueled by the difficulty of sustaining lifestyle changes and a
lack of convincing data supporting medical therapies. Bariatric surgery may be
offered to people with obesity if other treatment options have failed. Women who have bariatric surgery had lower cardio
metabolic risk factors, as evidenced by a better lipid profile and lower
insulin resistance.
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